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For 245 industrial chemicals, BG Chemie (after 2010 its legal successor is BG RCI) has published TOXICOLOGICAL EVALUATIONS. They give an overview on the acute and chronic effects of the substances and evaluate the data on the genotoxicity, carcinogenicity, reproductive toxicity, immunological and neurotoxic effects and the experiences in humans. The TOXICOLOGICAL EVALUATIONS are available in different versions which can either be downloaded or obtained free of charge. In addition, BG Chemie has performed 432 experimental studies with 129 phase-in substances. The studies are described in the TOXICOLOGICAL EVALUATIONS and can be obtained from BG RCI for registration under REACH.

Thiourea

CAS number 62-56-6, BG number 251

A TOXICOLOGICAL EVALUATION is available in a separate full-length printed German version (06/1995), in a short German version (06/1995) and in a full-length English version in Volume 12 of the book series “Toxicological Evaluations“, which you can download or order free of charge.

In the context of the “Programme for the Prevention of Health Hazards Caused by Industrial Substances”, a study on behalf of BG Chemie was conducted under the title “Untersuchungen zum Mechanismus und zur Bedeutung der Gentoxizität von Thioharnstoff in Säugetierzellen in vitro und in vivo – Gentoxizität und Metabolisierung von Thioharnstoff in menschlichen Schilddrüsen-Follikelzellen in vitro” (Studies on the mechanism and significance of thiourea genotoxicity in mammalian cells in vitro and in vivo – The genotoxicity and metabolism of thiourea in human thyroid follicle cells). Overall, the results obtained showed that thiourea was marginally genotoxic to human thyroid follicle cells. The genotoxicity was indicated by a slight increase in the frequency of DNA strand breaks in the cells and possibly due to slight auto oxidation of thiourea to electrophilic S oxygenated products. The investigations yielded no indication of organ-specific metabolic activation of thiourea in thyrocytes. It can therefore be assumed that human exposure to thiourea is not associated with a relevant risk of thyroid tumours due to genotoxic effects.

This study can be obtained from BG RCI for registration under REACH.

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