Analytical method for the determination of N-nitrosamines
Translation of DGUV Information 213-523 (former BGI 505-23 or ZH1/120.23)
| IUPAC Name | CAS Number |
| N-Nitrosodimethylamine | 62-57-9 |
| N-Nitrosomethylethylamine | 10595-95-6 |
| N-Nitrosodiethylamine | 55-18-5 |
| N-Nitrosodi-n-propylamine | 621-64-7 |
| N-Nitrosodiisopropylamine | 601-77-4 |
| N-Nitrosodibutylamine | 924-16-3 |
| N-Nitrosopiperidine | 100-75-4 |
| N-Nitrosopyrrolidine | 930-55-2 |
| N-Nitrosomorpholine | 59-89-2 |
A valid analytical method for the determination of N-nitrosamines is currently only available in German.
Method 04 – GC – withdrawn
Sampling with a pump and adsorption on a solid collection phase, capillary gas chromatography after elution.
This method permits the determination of N-nitrosamines concentrations in working areas averaged over the sampling time after personal or stationary sampling.
Principle
With a pump a measured air volume is drawn through an adsorption tube. After elution with a dichloromethane/methanol mixture the adsorbed N-nitrosamines are analysed using a gas chromatograph equipped with a thermal energy analyser (TEA) detector.
Limit of quantification (LOQ)
| N-Nitrosamine | absolute (ng) |
relative (µg/m³) for 200 L air sample, 1 mL sample solution, 5 μL injection volume |
| N-Nitrosodimethylamine | 0.019 | 0.03 |
| N-Nitrosomethylethylamine | 0.021 | 0.03 |
| N-Nitrosodiethylamine | 0.023 | 0.04 |
| N-Nitrosodi-n-propylamine | 0.036 | 0.06 |
| N-Nitrosodiisopropylamine | 0.032 | 0.05 |
| N-Nitrosodibutylamine | 0.051 | 0.08 |
| N-Nitrosopiperidine | 0.028 | 0.05 |
| N-Nitrosopyrrolidine | 0.028 | 0.05 |
| N-Nitrosomorpholine | 0.037 | 0.06 |
Issue
September 1992
Withdrawn
November 2018
The complete measuring method is available in the Wiley Online Library: Method for the determination of N-nitrosamines (Analyses of Hazardous Substances in Air, Volume 4, 1999).
Method 03 – GC – withdrawn
Sampling with a pump and adsorption on a solid collection phase, gas chromatography after elution.
This method permits the determination of N-nitrosamines concentrations in working areas averaged over the sampling time after personal or stationary sampling.
Principle
With a pump a measured air volume is drawn through an adsorption tube. After elution with a dichloromethane/methanol mixture the adsorbed N-nitrosamines are analysed using a gas chromatograph equipped with a thermal energy analyser (TEA) detector.
Limit of quantification (LOQ)
| N-Nitrosamine | absolute (ng) |
relative (µg/m³) for 200 L air sample, 1 mL sample solution, 5 μL injection volume |
| N-Nitrosodimethylamine | 0.1 | 0.1 |
| N-Nitrosomethylethylamine | 0.1 | 0.1 |
| N-Nitrosodiethylamine | 0.1 | 0.1 |
| N-Nitrosodi-n-propylamine | 0.1 | 0.1 |
| N-Nitrosodiisopropylamine | 0.1 | 0.1 |
| N-Nitrosodibutylamine | 0.2 | 0.2 |
| N-Nitrosopiperidine | 0.1 | 0.1 |
| N-Nitrosopyrrolidine | 0.2 | 0.2 |
| N-Nitrosomorpholine | 0.2 | 0.2 |
Issue
September 1992
Withdrawn
November 2018
The complete measuring method is available in the Wiley Online Library: Method for the determination of N-nitrosamines (Analyses of Hazardous Substances in Air, Volume 4, 1999).
You can reach the German-language version of the article with a single click on the flag-symbol.
