Analytical method for the determination of 1,2-epoxybutane
Translation of DGUV Information 213-556 (former BGI 505-56 or ZH1/120.56)
CAS Number: 106-88-7
Synonyms:
- 1,2-Butylene oxide
- Ethyloxirane
Method 03 – Headspace GC/MS
Sampling is carried out with a pump and adsorption on charcoal. Analysis is performed by headspace gas chromatography with mass selective detection (GC/MS).
This method can be used with personal or stationary sampling to determine the mean concentration of 1,2-epoxybutane (1,2-butylene oxide) at workplaces over the sampling time.
Principle
A pump draws a defined volume of air through a glass tube filled with charcoal. The adsorbed 1,2-epoxybutane is desorbed with a mixture of N,N-dimethylacetamide/ water (water content approx. 20% by volume). The analytical determination is achieved by headspace gas chromatography and detection with a mass selective detector.
Limit of quantification (LOQ)
Relative: 0.15 mg/m3 of 1,2-epoxybutane based on a 6 L air sample, 5 mL sample solution and an injection volume of 0.5 mL from the headspace.
Issue
February 2007
The complete measuring method is available in the Wiley Online Library: Method for the determination of 1,2-epoxybutane (1,2-butylene oxide) (Air Monitoring Methods, Volume 12, 2011).
Method 02 – GC – limited suitability: category E2
Sampling with a pump and adsorption on activated carbon, gas chromatography after desorption.
This method permits the determination of 1,2-epoxybutane concentrations in working areas averaged over the sampling time after personal or stationary sampling.
Principle
With a pump a measured air volume is drawn through a glass tube filled with activated carbon. The adsorbed 1,2-epoxybutane is then desorbed with a mixture of dichloromethane/carbon disulfide/methanol and determined by gas chromatography.
Limit of quantification (LOQ)
Absolute: 8 ng 1,2-epoxybutane.
Relative: 0.5 mg/m3 1,2-epoxybutane for a 20 litre air sample, 2.5 mL of desorption solution and 2 µL injection volume.
Issue
November 1994
The measuring method is of limited suitability (E2).
The complete measuring method is available in the Wiley Online Library: Method for the determination of 1,2-epoxybutane (1,2-butylene oxide) (Analyses of Hazardous Substances in the Air, Volume 7, 2003).
Method 01 – GC
Sampling with a pump and adsorption on polymeric resin Amberlite XAD-4, gas chromatography after thermal desorption.
This method permits the determination of 1,2-epoxybutane concentrations in working areas averaged over the sampling time after personal or stationary sampling.
Principle
With a pump a measured air volume is drawn through a metal tube filled with XAD-4. The adsorbed 1,2-epoxybutane is then desorbed by heating in a thermal desorber and determined by gas chromatography.
Limit of quantification (LOQ)
Absolute: 20 ng 1,2-epoxybutane per adsorption tube.
Relative: 0.1 mg/m3 1,2-epoxybutane for a 200 mL air sample.
Issue
November 1994
The complete measuring method is available in the Wiley Online Library: Method for the determination of 1,2-epoxybutane (1,2-butylene oxide) (Analyses of Hazardous Substances in the Air, Volume 7, 2003).
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