Analytical method for the determination of dimethyl sulfate
Translation of DGUV Information 213-507 (former BGI 505-07 or ZH1/120.7)
CAS Number: 77-78-1
Synonym: DMS
The methods are also suitable for determining other dialkylsulfates.
Method 05 – GC
Sampling is carried out with a pump and adsorption on Tenax. Analysis is performed by gas chromatography with mass selective detection (GC/MS) after thermal desorption.
This method can be used with personal or stationary sampling to determine the mean concentration of dimethyl sulfate at workplaces over the sampling time.
Principle
A pump draws a defined volume of air through a metal tube filled with Tenax. The adsorbed dimethyl sulfate is then thermally desorbed and determined by gas chromatography.
Limit of quantification (LOQ)
Absolute: 23 ng of dimethyl sulfate
Relative: 0.9 µg/m³ of dimethyl sulfate for a 25 L air sample.
Issue
October 2006
The complete measuring method is available in the Wiley Online Library: Method for the determination of dimethyl sulfate (Air Monitoring Methods, Volume 12, 2011).
Method 04 – GC
Sampling with a pump, adsorption on Tenax-TA, desorption, gas chromatography and mass-selective detection
This method permits the determination of dimethyl sulfate (DMS) concentrations in working areas averaged over the sampling time after personal or stationary sampling.
Principle
With a pump a measured air volume is drawn through a Tenax tube. The adsorbed dimethyl sulfate is desorbed with toluene and analysed using a gas chromatograph with mass selective detector.
Limit of quantification (LOQ)
Absolute: 0,4 ng dimethyl sulfate.
Relative: 0.01 mg/m3 dimethyl sulfate for 20 L air sample, 1 mL of desorption solution and 2 µL injection volume.
Issue
April 1997
The complete method is available in the Wiley Online Library: Method for the determination of dimethyl sulfate (DMS) (Analyses of Hazardous Substances in Air, Volume 5, 2002).
Method 03 – GC – withdrawn
Sampling with a pump, adsorption on Tenax-TA, desorption and gas chromatography
This method permits the determination of dimethyl sulfate (DMS) concentrations in working areas averaged over the sampling time after personal or stationary sampling.
Principle
With a pump a measured air volume is drawn through Tenax-TA. After desorption with methyl acetate, dimethyl sulfate is determined using gas chromatography with a sulfur-specific flame-photometric detector (FID).
Limit of quantification (LOQ)
Absolute: 3 ng dimethyl sulfate.
Relative: 0.003 mL/m³ (ppm) ≙ 0.015 mg/m³ dimethyl sulfate for 10 L air sample.
Issue
January 1987
Withdrawn
May 2014
The complete method is available in the Wiley Online Library: Method for the determination of dimethyl sulfate (DMS) (Analyses of Hazardous Substances in Air, Volume 5, 2002).
Method 02 – GC – withdrawn
Sampling with a pump, adsorption on silica gel, desorption and gas chromatography.
This method permits the determination of dimethyl sulfate (DMS) concentrations in working areas averaged over the sampling time after stationary sampling.
Principle
With a pump a measured air volume is drawn through silica gel. After desorption with acetone, the dimetyhl sulfate is determined using gas chromatography with a sulfur-specific flame photometric detector (FPD).
Limit of quantification (LOQ)
Absolute: 3 ng dimethyl sulfate.
Relative: 0.008 mL/m³ (ppm) ≙ 0.04 mg/m3 dimethyl sulfate for 100 L air sample.
Issue
December 1983
Withdrawn
December 2005
The complete method is available in the Wiley Online Library: Method for the determination of dimethyl sulfate (DMS) (Analyses of Hazardous Substances in Air, Volume 5, 2002).
Method 01 – DC – withdrawn
Sampling with a pump, adsorption on silicagel, desorption, derivatisation and thin-layer chromatography
This method permits the determination of dimethyl sulfate (DMS) concentrations in working areas averaged over the sampling time after stationary sampling.
Principle
With a pump a measured air volume is drawn through silica gel. After desorption with acetone and derivatisation with 4-nitrophenol sodium, the dimethyl sulfate is determined as 4-nitroanisole by thin-layer chromatography.
Limit of quantification (LOQ)
Absolute: 50 ng dimethyl sulfate when using silica gel 60 pre-coated TLC plates.
Relative: 0.02 mL/m³ (ppm) ≙ 0.1 mg/m3 dimethyl sulfate for 100 L air sample.
Issue
December 1983
Withdrawn
December 2005
The complete method is available in the Wiley Online Library: Method for the determination of dimethyl sulfate (DMS) (Analyses of Hazardous Substances in Air, Volume 5, 2002).
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