Analytical method for the determination of 4,4'-diaminodiphenylmethane

Translation of DGUV Information 213-539 (former BGI 505-39 or ZH1/120.39)

CAS Number: 101-77-9

Synonyms: 

• MDA
• 4,4'-Methylenedianiline

Method 03 – HPLC – limited suitability: category E1

Sampling with a pump and adsorption on an impregnated filter. High performance liquid chromatography (HPLC) after elution.

This method permits the determination of the 4,4'-diaminodiphenylmethane concentration in working areas averaged over the sampling time. Both personal or stationary sampling are possible.

Principle

With a pump a measured air volume is drawn through a glass fibre filter impregnated with sulfuric acid. The adsorbed 4,4'-diaminodiphenylmethane is eluted with water and determined by high performance liquid chromatography.

Limit of quantification (LOQ)

Absolute: 0.05 µg 4,4'-diaminodiphenylmethane.

Relative: 0.008 mg/m³ 4,4'-diaminodiphenylmethane for 500 L air sample, 4 mL elution solution and 50 µL injection volume.

Issue

November 1994

The measuring method is of limited suitability (E1).

The complete measuring method is available in the Wiley Online Library: Methods for the determination of 4,4'-diaminodiphenylmethane (4,4'-methylenedianiline) (Analyses of Hazardous Substances in Air, Volume 4, 1999).

Go to the Wiley Online Library

Method 02 – Photometry – limited suitability: category E1

Sampling with a pump and adsorption on an impregnated filter. Photometry after derivatisation.

This method permits the determination of the 4,4'-diaminodiphenylmethane concentration in working areas averaged over the sampling time. Both personal or stationary sampling are possible.

Principle

With a pump a measured air volume is drawn through a glass fibre filter impregnated with sulfuric acid. The collected 4,4'-diaminodiphenylmethane is eluted with hydrochloric acid and converted into a blue-violet azo dye after diazotization and addition of a coupling agent. Analysis is performed photometrically.

Limit of quantification (LOQ)

Absolute: 2 µg 4,4'-diaminodiphenylmethane for 25 mL analysis solution and 1 cm optical path length.

Relative: 0.008 mg/m³ 4,4'-diaminodiphenylmethane for 500 L air sample, 25 mL analysis solution and 1 cm optical path length.

Issue

November 1994 

The measuring method is of limited suitability (E1).

The complete measuring method is available in the Wiley Online Library: Methods for the determination of 4,4'-diaminodiphenylmethane (4,4'-methylenedianiline) (Analyses of Hazardous Substances in Air, Volume 4, 1999).

Go to the Wiley Online Library

Method 01 – Photometry – withdrawn

Sampling with a pump and adsorption on impregnated silica gel. Photometry after derivatisation.

This method permits the determination of the 4,4'-diaminodiphenylmethane concentrations in working areas averaged over the sampling time after personal or stationary sampling.

Principle

A measured air volume is drawn through an adsorption tube containing silica gel which is impregnated with sulfuric acid. The 4,4'-diaminodiphenylmethane is bound as the sulfate.

The adsorbed 4,4'-diaminodiphenylmethane is eluted and after diazotization and coupling addition of a agent it is converted into a blue-violet azo dye. The analytical determination is carried out by photometry.

Limit of quantification (LOQ)

Absolute: 2 µg 4,4'-diaminodiphenylmethane for 25 mL analysis solution and 1 cm optical path length.

Relative: 0.025 mg/m³ 4,4'-diaminodiphenylmethane for 320 L air sample, 25 mL analysis solution and 1 cm optical path length.

Issue

January 1989

Withdrawn

The complete measuring method is available in the Wiley Online Library: Methods for the determination of 4,4'-diaminodiphenylmethane (4,4'-methylenedianiline) (Analyses of Hazardous Substances in Air, Volume 4, 1999).

Go to the Wiley Online Library